The purpose of this study is to evaluate whether a single fraction of radiotherapy given intra-operatively and targeted to the tissues at the highest risk of local recurrence is equivalent to standard post-operative external beam radiotherapy after breast conserving surgery in women with early stage breast cancer in terms of local relapse within the treated breast. This study has ended recruitment.
Study Status: THIS STUDY IS NOW CLOSED TO ENROLLMENT. THE FINAL RESULTS HAVE BEEN PUBLISH, with Dr. Holmes as a co-author. With an average of 8 year follow-up (including 18 years of follow-up of the first. enrolled patients), the TARGIT-A trial showed no difference in the breast cancer recurrence and survival rates between women who received targeted intraoperative radiotherapy and traditional whole breast radiation.
Click here to Read the publication: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61950-9/fulltext
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