Universal Breast Cancer Genetic Testing Registry

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Background

The Universal Breast Cancer Genetic Testing Registry is a national research registry that will enroll 1,000 breast cancer patients across 20-25 TME practices in the United States.  We compared the frequency of positive genetic test results in 500 women that met National Comprehensive Cancer Network (NCCN) criteria for genetic testing to 500 women who did not meet criteria.  All enrollees were tested with Invitae’s multi-cancer panel, an 80-gene hereditary cancer test that includes genes associated with hereditary cancers in eight major organ systems.  The study found NO significant difference between the two groups in terms of the rate of positive genetic tests results (9% vs 8%), which means that current NCCN guidelines are too stringent.  This study's findings led to a new national guideline recommendation from the American Society of Breast Surgeons that ALL breast cancer patients should offered genetic testing, regardless of their risk factors.  

Primary Objective

To determine if providing all breast cancer patients with broad multi-gene panel genetic testing yields additional clinical value.

Study Status

COMPLETED. Published 

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Sponsors and Collaborators

  

TME (Targeted Medical Education) Research

Invitae

Study Contact

Allison Zimmerman

Research Coordinator

Helen Rey Breast Cancer Research Foundation

Telephone: 818-539-1985 Fax: 818-539-1985